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Generic Name
Chlorothiazide
Trade Name
Chlorothiazide
Risk Category
C
  • Studies on animals show adverse effect and toxicity on fetus.
  • No adequate and well controlled studies done on pregnant women.
  • Drugs should be given only if the potential benefit outweighs the potential risk to the fetus.
FDA Pregnancy Risk Categories

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Indication
Indication
  • diuretic, thiazide group.
  • Fetal Risk
    Fetal Risk
  • Limited human data, especially in 1st trimester but not reported to be teratogenic.
  • Crosses human uterus, which is attached to embryo and walls of uterus">placenta at term.
  • Thiazides are diabetogenic and new borns may develop hypoglycemia at birth.
  • Thiazides used near term may cause neonatal thrombocytopenia and hemolytic anemia.
  • Thiazides may cause maternal hypotension and electrolyte imbalance (hypokalemia) with subsequent effects on the fetus and newborn (fetal bradycardia, fetal death, and neonatal hypotonia and hyponatremia) use of chlorothiazides in 2nd and 3rd trimesters may cause maternal acute hemorrhagic pancreatitis with subsequent maternal and fetal death.
  • Thiazides may affect the smooth muscle of uterus and inhibit labor.
  • Breast Feeding
    Breast Feeding
  • Excreted into milk in small amounts.
  • Safe in breast-feeding although it may suppress lactation
  • Potential to cause thrombocytopenia in nursing infants but not proved.
  • Other Trade Names
     
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