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Generic Name
Trade Name
Risk Category
  • Studies on animals show adverse effect and toxicity on fetus.
  • No adequate and well controlled studies done on pregnant women.
  • Drugs should be given only if the potential benefit outweighs the potential risk to the fetus.
FDA Pregnancy Risk Categories

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  • diuretic, thiazide group.
  • Fetal Risk
    Fetal Risk
  • Limited human data, especially in 1st trimester but not reported to be teratogenic.
  • Crosses human uterus, which is attached to embryo and walls of uterus">placenta at term.
  • Thiazides are diabetogenic and new borns may develop hypoglycemia at birth.
  • Thiazides used near term may cause neonatal thrombocytopenia and hemolytic anemia.
  • Thiazides may cause maternal hypotension and electrolyte imbalance (hypokalemia) with subsequent effects on the fetus and newborn (fetal bradycardia, fetal death, and neonatal hypotonia and hyponatremia) use of chlorothiazides in 2nd and 3rd trimesters may cause maternal acute hemorrhagic pancreatitis with subsequent maternal and fetal death.
  • Thiazides may affect the smooth muscle of uterus and inhibit labor.
  • Breast Feeding
    Breast Feeding
  • Excreted into milk in small amounts.
  • Safe in breast-feeding although it may suppress lactation
  • Potential to cause thrombocytopenia in nursing infants but not proved.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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