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Generic Name
Trade Name
Risk Category
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
FDA Pregnancy Risk Categories

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  • Anticoagulant.
  • Fetal Risk
    Fetal Risk
  • 1st trimester exposure causes fetal warfarin syndrome (FWS) or embryopathy: developmental and growth retardation, eye defects, hearing loss, cardiac defects, nasal and limb hypoplasia, seizures.
  • Exposure to coumarine derivatives during 2nd and 3rd trimesters causes central nervous system (spinal cord">spinal cord">cns) defects (mental retardation, Blindness, deafness seizures, spasticity, agenesis of corpus callosum, Dandy-Walker malformation, encephalocele, cerebellar atrophy)
  • Use of coumarine derivatives during pregnancy can cause abortions, stillbirths, prematurity and hemorrhage (cerebral hemorrhage).
  • Suggested association between the use of coumarine derivatives and congenital anomalies unrelated to FWS and spinal cord">spinal cord">cns defects such as: Anencephaly, spina bifida, fetal distress, seizures, polydactyly, single kidney, cleft palate, hypoplasia of the lung and diaphragm corneal leukoma, asplenia, incomplete rotation of the gut.
  • Follow up of children exposed in utero to coumarine derivatives showed low IQ scores and low neurologic assessments
  • Breast Feeding
    Breast Feeding
  • Safe in breast feeding.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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