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Generic Name
Etretinate
Trade Name
Etretinat
Risk Category
X
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
  • Studies in animals and/or humans have demonstrated fetal abnormalities.
  • Fetal risk involved in use of drug, clearly outweighs potential benefit.
  • Contraindicated in women who are or may become pregnant. Don’t use.
FDA Pregnancy Risk Categories

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Indication
Indication
  • Vitamin A derivative for treatment of psoriasis.
  • Fetal Risk
    Fetal Risk
  • teratogenic in animals.
  • It has long half-life and stored in maternal fat tissues and can be released for prolonged periods.
  • teratogenic in human pregnancy and also in pregnancies following discontinuation of the treatment causing skeletal defects, central nervous system, head, face,and heart defects.
  • Suggested association between in utero exposure to etretinate and CHARGE association (coloboma, heart defects, atresia: Congenital absence or narrowing of gall bladder canal">choanal atresia, retardation, genital and ear defects).
  • Neonatal jaundice and elevated liver enzymes were reported after in utero exposure to the drug.
  • Males treated with the drug should avoid fathering during treatment because of suggested association with congenital defects in their children.
  • Breast Feeding
    Breast Feeding
  • Contraindicated during breast-feeding.
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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