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Generic Name
Ergotamine
Trade Name
Lingraine
Risk Category
X
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
  • Studies in animals and/or humans have demonstrated fetal abnormalities.
  • Fetal risk involved in use of drug, clearly outweighs potential benefit.
  • Contraindicated in women who are or may become pregnant. Don’t use.
FDA Pregnancy Risk Categories

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Indication
Indication
  • sympatholytic.
  • Ergot alkaloid for treatment of migraine.
  • Fetal Risk
    Fetal Risk
  • Not teratogenic in animals but fetotoxic at maternal toxic dose causing growth retardation, fetal death and abortion.
  • Crosses human uterus, which is attached to embryo and walls of uterus">placenta, has oxytocic effect on the uterus causing tetanic contractions leading to fetal hypoxia and death.
  • Possible association between 1st trimester exposure and congenital defects including neural tube-neural crest dysplasia (hydrocephalus, sacral agenesis, digital and muscle hypoplasia, joint contractures, short stature and pilonidal sinus).
  • High doses or chronic use of the drug is associated with fetal vascular injuries related to vasospasm induced by the drug resulting in intestinal atresia, arrest of cerebral and spinal cord development (microcephaly, hypotonia of limbs, paraplegia and arthrogryposis multiplex).
  • Breast Feeding
    Breast Feeding
  • Excreted into milk.
  • Contraindicated in breast-feeding, as it causes vomiting, diarrhea and convulsions in nursing infants.
  • It may suppress lactation.
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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