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Generic Name
Ergotamine tartrate, Chlorcyclizine , caffeine and meprobamate
Trade Name
Anervan
Risk Category
D*
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
The risk category is B for Caffeine.
The risk category is C for Chlorcyclizine.
The risk category is D For Ergotamine and Meprobamate.
FDA Pregnancy Risk Categories

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Indication
Indication
  • Use For treatment of migraine.
  • Fetal Risk
    Fetal Risk
  • Ergotamine is fetotoxic in animals at maternal toxic doses causing maternal blood, thus allow the fetus to grow">uterus">intrauterine growth retardation, fetal death and abortion. It has oxytocic effect on maternal blood, thus allow the fetus to grow">uterus causing tetanic contractions leading to fetal hypoxia and death.
  • Suggested possible association with congenital malformation including neural tube – neural crest dysplasia (hydrocephalus, sacral agenesis, digital and muscle hypoplasia).
  • High doses or chronic use is associated with fetal vascular injuries related to vasospasm induced by the drug resulting in intestinal atresia, arrest of cerebral and spinal cord development (microcephaly, paraplegia, hypotonia).
  • Caffeine is teratogenic in animals maternal toxic doses.
  • No adequate human data but suggested association between high maternal caffeine intake and decreased fertility, increased abortion rate, low birth weight, growth retardation and preterm delivery.
  • maternal ingestion of more than 500 mg/ day of caffeine may cause neonatal cardiac arrythmias as a feature of drug withdrawal, and change in fetal behavior (frequent body movement, irregular heart rate and breathing activity).
  • No data available for Chlorcyclizine in pregnancy.
  • Reported association between meprobamate use in pregnancy and congenital defects including heart defects, Down's syndrome Deafness, limb defects and polydactyly.
  • Breast Feeding
    Breast Feeding
  • Unknown effects of meprobamate and chlorcyclizine on nursing infants.
  • Ergotamine is contraindicated as it causes vomiting, diarrhea and convulsions in nursing infants.
  • Heavy amounts of caffeine may cause irritability and poor sleeping in nursing infants, usual amounts are safe.
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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