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Generic Name
Norethisterone acetate Estradiol
Trade Name
Estragest TTS
Risk Category
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
  • Studies in animals and/or humans have demonstrated fetal abnormalities.
  • Fetal risk involved in use of drug, clearly outweighs potential benefit.
  • Contraindicated in women who are or may become pregnant. Don’t use.
The risk category is D for Norethisterone.
FDA Pregnancy Risk Categories

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  • Hormonal replacement therapy.
  • Fetal Risk
    Fetal Risk
  • 1st trimester exposure to progestational agents in general reported to cause cardio vascular defects and hypospadias.
  • No well - controlled data for norethisterone.
  • Exposure to estrogens is a possible cause of cardiovascular,eye, ear defects and Down's syndrome.
  • Males exposed in utero to estrogen - progesterone may have psycho sexual changes (less heterosexual experience, fever musculine interests).
  • Breast Feeding
    Breast Feeding
  • Both agents are excreted into milk and are safe although estrogens suppress lactation.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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