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Generic Name
Dextromethorphan, Ephedrine and Chlorpheniramine maleate
Trade Name
R+N pharm
Risk Category
  • Studies on animals show adverse effect and toxicity on fetus.
  • No adequate and well controlled studies done on pregnant women.
  • Drugs should be given only if the potential benefit outweighs the potential risk to the fetus.
The risk category is B for chlorpheniramine.
FDA Pregnancy Risk Categories

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  • decongestant, antitussive.
  • Fetal Risk
    Fetal Risk
  • No animal data for dextromethorphan limited human data, considered safe in pregnancy.
  • Ephedrine is teratogenic in animals. No adequate human data but for sympathomimetic drugs in general have been reported association with minor congenital anomalies, inguinal hernia and club foot if used in 1st trimester.
  • It also causes fetal tachycardia. No well – controlled human data for chlorpheniramine, suggested possible association with congenital malformations including polydactyly, eye, ear defects, inguinal hernia, gastrointestinal and genital defects, dislocation of the hip.
  • Use of antihistamines in the last two weeks of pregnancy reported to cause retrolental fibroplasia in premature infants.
  • Breast Feeding
    Breast Feeding
  • No data available for dextromethorphan and chlorpheniramine in breast feeding.
  • Ephedrine considered safe, reported single case of irritability and poor sleeping in nursing infant.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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