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Generic Name
Atenolol and Nifedipine
Trade Name
Nif - ten
Manufacturer
Zeneca
Risk Category
D*
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
The risk category is C for Nifedipine.
FDA Pregnancy Risk Categories

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Indication
Indication
  • beta-blocker and calcium channel blocker for treatment of hypertension and angina pectoris.
  • Fetal Risk
    Fetal Risk
  • Atenolol is not teratogenic in animals but toxic at high doses causing embryonic and fetal resorption.
  • It crosses human placenta and there is suggested association with hypospadias in 1st trimester exposure, and with retroperitoneal fibromatosis in children exposed to the drug in utero.
  • Causes intrauterine growth retardation and persistent beta-blockade in newborns if used in the last two trimesters.
  • Nifedipine is embryotoxic and teratogenic in animals at high doses.
  • No well–controlled human data available but suggested association with cardiovascular defects in 1st trimester exposure and with growth retardation in 2nd and 3rd trimesters' exposure.
  • Breast Feeding
    Breast Feeding
  • Atenolol is excreted and accumulates in the milk.
  • It causes beta-blockade in nursing infants so safer alternatives are recommended.
  • Nifedipine is excreted into milk and is safe in breast feeding.
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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