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Generic Name
Atenolol and Chlorthalidone
Trade Name
Blokium Diu
Risk Category
D
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
FDA Pregnancy Risk Categories

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Indication
Indication
  • Cardioselective beta-adrenergic blocking agent.
  • Antihypertensive.
  • Fetal Risk
    Fetal Risk
  • Not teratogenic in animals but toxic at high doses causing embryonic and fetal resorptions.
  • Crosses human placenta.
  • Suggested association with hypospadias in 1st trimester exposure.
  • Reported association with retroperitoneal fibromatosis in a fetus exposed to the drug in utero.
  • Causes intrauterine growth retardation and persistent beta-blockade in newborns if used in the last two trimesters. Causes fetal bradycardia.
  • Breast Feeding
    Breast Feeding
  • Excreted into milk.
  • Causes beta-blockade in infants exposed and as it accumulates in milk, safer alternatives are recommended.
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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