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Generic Name
Dihydroergotamine mesilate (Nasal - systemic)
Trade Name
Risk Category
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
  • Studies in animals and/or humans have demonstrated fetal abnormalities.
  • Fetal risk involved in use of drug, clearly outweighs potential benefit.
  • Contraindicated in women who are or may become pregnant. Don’t use.
FDA Pregnancy Risk Categories

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  • Antimigrane agent.
  • Ergot derivative.
  • Fetal Risk
    Fetal Risk
  • In animals it causes decreased fetal body weight and skeletal ossification.
  • No well controlled human data but the drug is contraindicated in pregnancy because it has oxytocic effect on the uterus resulting in vasoconstriction of uterine vessels, reduction of utero-placental blood flow and intrauterine growth retardation.
  • Breast Feeding
    Breast Feeding
  • ergot alkaloids are excreted into milk and can cause vomiting, diarrhea, unstable blood pressure and weak pulse in nursing infants.
  • Unknown excretion of intranasal dihydro-ergotamine into milk.
  • Should be avoided during breast feeding.
  • ergot alkaloids also inhibit lactation.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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