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Generic Name
Trade Name
Risk Category
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
FDA Pregnancy Risk Categories

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  • Derivative of podophyllotoxin, antineoplastic.
  • Fetal Risk
    Fetal Risk
  • teratogenic and embryotoxic in animals causing low birth weight, skeletal defects, encephalocele, anophthalmia, exencephaly and other brain defects.
  • No human data in first trimester but exposure to the drug in the second and third trimesters resulted in growth retardation, oligohydramnios, bone marrow depression and reversible alopecia.
  • Occupational exposure of pregnant women to antineoplastic drugs may carry a risk to the fetus including fetal loss and malformations.
  • Breast Feeding
    Breast Feeding
  • Excreted into human milk.
  • Potential for severe bone marrow depression, alopecia, carcinogenicity in nursing infants, so should be avoided during lactation.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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