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Generic Name
Captopril and hydrochlorothiazide
Trade Name
Capocard plus
Manufacturer
Dar Al Dawa
Risk Category
D*
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
The risk category is C in the first trimester.
FDA Pregnancy Risk Categories

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Indication
Indication
  • Antihypertensive.
  • Angiotensin-converting enzyme (ACE) inhibitor .
  • Thiazide diuretic.
  • Fetal Risk
    Fetal Risk
  • Captopril is embryocidal in animals increasing the stillbirth rate.
  • No well-controlled human studies in 1st trimester but no association with congenital anomalies has been reported.
  • The drug is teratogenic and fetotoxic if used in 2nd and 3rd trimesters causing:- oligohydramnios leading to skull deformities, limb contractures, pulmonary hypoplasia, intrauterine growth retardation, renal tubular dysplasia leading to neonatal anuria and renal failure, severe neonatal hypotension, prematurity and intrauterine fetal death.
  • Breast Feeding
    Breast Feeding
  • Both agents are excreted in breast milk.
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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