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Generic Name
Acetylsalicylic acid (0.33 g) and Ascorbic acid (0.2g)
Trade Name
Cebiopirin
Manufacturer
Merck
Risk Category
C*
  • Studies on animals show adverse effect and toxicity on fetus.
  • No adequate and well controlled studies done on pregnant women.
  • Drugs should be given only if the potential benefit outweighs the potential risk to the fetus.
The risk category is C for Acetylsalicylic Acid only if used in low doses (< 150 mg /day).
The risk category is C for Ascorbic Acid.
The risk category is D for Acetylsalicylic Acid only if used in full doses in 3rd trimester.
FDA Pregnancy Risk Categories

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Indication
Indication
  • analgesic, antipyretic.
  • For common cold.
  • Fetal Risk
    Fetal Risk
  • The dose of ascorbic acid is above the recommended dietary allowance (rda) in pregnancy.
  • No well-controlled human data but suggested association between high doses and anencephaly and infantile scurvy.
  • The dose of acetylsalicyclic acid is also high and if used in the last trimester of pregnancy, it can cause premature closure of pulmonary artery to aorta">ductus arteriosus with subsequent neonatal pulmonary hypertension, intrauterine growth retardation, stillbirth and bleeding disorders of the newborn.
  • It can also cause congenital salicylate intoxication.
  • Reported possible association between its use in 1st trimester and congenital anomalies (heart defects and oral clefts).
  • Questionable effect of high doses on the IQ of children exposed in utero in the first half of pregnancy
  • Breast Feeding
    Breast Feeding
  • Acetylsalicylic acid is excreted into milk in small amounts but should be used with caution because it may affect platelet function of nursing infants.
  • The dose of ascorbic acid is above the rda in breast feeding but can be used safely.
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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