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Generic Name
Triprolidine HCl, pseudoephedrine HCl and Codeine phosphate
Trade Name
Actifed Compound Linctus
Risk Category
  • Studies on animals show adverse effect and toxicity on fetus.
  • No adequate and well controlled studies done on pregnant women.
  • Drugs should be given only if the potential benefit outweighs the potential risk to the fetus.
FDA Pregnancy Risk Categories

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  • Antitussive.
  • Antihistamine.
  • Decongestant.
  • Fetal Risk
    Fetal Risk
  • No fetal adverse effects have been reported with triprolidine in animal studies, no well-controlled human data, suggested possible association with cardiovascular defects in 1st trimester exposure.
  • No adequate human data for pseudoephedrine but suggested possible association with umbilical cord">gastroschisis in 1st trimester exposure and for sympathomimetic drugs in general they are teratogenic in animals and possibly associated with minor malformations, club foot and inguinal hernias in human pregnancy.
  • No well-controlled data for codeine, but suggested possible association with respiratory, genito-urinary malformations, downs syndrome, umbilical and inguinal hernias, pyloric stenosis and hydrocephaly . Opiates in general are suggested to produce cleft lip\palate, heart , musculoskeletal , gastroinestinal malformations and inguinal hernias. High doses of codeine at term can cause neonatal withdrawal and respiratory depression.
  • Breast Feeding
    Breast Feeding
  • Triprolidine and pseudoephedrine are excreted into milk and safe in breast feeding.
  • Codeine is also safe in breast feeding.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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