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Generic Name
Sulphamethoxazole and Trimethoprim
Trade Name
Shatrim
Risk Category
C
  • Studies on animals show adverse effect and toxicity on fetus.
  • No adequate and well controlled studies done on pregnant women.
  • Drugs should be given only if the potential benefit outweighs the potential risk to the fetus.
FDA Pregnancy Risk Categories

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Indication
Indication
  • Both are antibacterial agents and their combination produces synergistic antibacterial activity.
  • Fetal Risk
    Fetal Risk
  • Cross the placenta.
  • May affect folic acid matabolism in the fetus.
  • Suggested risk of cleft palate.
  • Breast Feeding
    Breast Feeding
  • Excreted in breast milk
  • Sulfonamides may cause kernicterus in nursing infants.
  • Trimethoprim may interfere with folic acid metabolism in nursing infants.
  • American Academy of Padiatrics considers sulf.-trim.
  • Combination to be compatible with nursing.
  • Other Trade Names
     
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