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Generic Name
Sulphamethoxazole and Trimethoprim
Trade Name
Risk Category
  • Studies on animals show adverse effect and toxicity on fetus.
  • No adequate and well controlled studies done on pregnant women.
  • Drugs should be given only if the potential benefit outweighs the potential risk to the fetus.
FDA Pregnancy Risk Categories

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  • Both are antibacterial agents and their combination produces synergistic antibacterial activity.
  • Fetal Risk
    Fetal Risk
  • Cross the placenta.
  • May affect folic acid matabolism in the fetus.
  • Suggested risk of cleft palate.
  • Breast Feeding
    Breast Feeding
  • Excreted in breast milk
  • Sulfonamides may cause kernicterus in nursing infants.
  • Trimethoprim may interfere with folic acid metabolism in nursing infants.
  • American Academy of Padiatrics considers sulf.-trim.
  • Combination to be compatible with nursing.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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