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Generic Name
Enalapril and Hydrochlorothiazide
Trade Name
Risk Category
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
The risk category is C in first trimester.
FDA Pregnancy Risk Categories

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  • antihypertensive.
  • Angiotensin-1 convrting enzyme inhibitor (ACE) with diuretic of thiazide group.
  • Fetal Risk
    Fetal Risk
  • Enalapril is fetotoxic in animals causing growth retardation and incomplete bone ossificaiton. No adequate human data in 1st trimester but suggested possible association with cardiovascular defects and polydactyly.
  • Use of enalapril in second and third trimesters causes fetal growth retardation, olighydramnios leading to skull deformities, lung hypoplasia and limb contractures, prematurity, fetal destress, neonatal kidney injury and anuria.
  • Limited human data for hydrochlorothiazide, no teratogenic effects have been reported. Thiazides in general can cause neonatal thrombocytopenia if used near term and hypoglycemia. Thiazides may cause maternal hypotension and electrolyte imbalance resulting in fetal bradycardia, death, neonatal hypotonia and hyponatremia.
  • Breast Feeding
    Breast Feeding
  • Both agents are excreted into milk in small amounts and both are safe although hydrochlorothiazide may suppress lactation and potential to cause thrombocytopenia in nursing infants.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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