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Generic Name
Reserpine, hydralazine and Hydrochlorothiazide
Trade Name
Ser-Ap-Es
Risk Category
C
  • Studies on animals show adverse effect and toxicity on fetus.
  • No adequate and well controlled studies done on pregnant women.
  • Drugs should be given only if the potential benefit outweighs the potential risk to the fetus.
FDA Pregnancy Risk Categories

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Indication
Indication
  • Use antihypertensive.
  • Fetal Risk
    Fetal Risk
  • No adequate data for reserpine but suggested possible association with microcephaly hydronephrosis and hydroureter, and if used near term, it can cause nasal discharge lethargy and anorexia in the newborns.
  • No well - controlled human data for dihydralazine, suggested possible association with hypospadias in 1st trimester exposure and with neonatal thrombocytopenia in 3rd trimester, and reported to cause fetal tachyarrythmias and lupus - like symptoms.
  • No teratogenic effects has been reported with hydrochlorothiazide use in pregnancy but thiazides in general as a group can cause neonatal thrombocytopenia hypoglycemia hyponatremia, hypotonia fetal bradycardia and death.
  • Thiazides inhibit labor by affecting the smooth muscles of the uterus.
  • Breast Feeding
    Breast Feeding
  • All drugs are excreted into milk. Dihydralazine is safe in breast feeding.
  • No adverse effects has been reported with reserpine in nursing infants, but hydrochlorothiazide is potential to cause thrombocytopenia.
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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