Enter your email address to receive updates
Search By Trade Name
Trade name | Generic name | Classification
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z 
Generic Name
Indomethacin, (indometacin)
Trade Name
Methacin
Manufacturer
JPM
Risk Category
B*
  • Controlled studies done on animals in reproduction do not indicate risk to the fetus.
  • No adequate and well-controlled studies done on pregnant women.
The risk category will be D only if used longer than 48 hours or after 34 weeks gestation.
FDA Pregnancy Risk Categories

Place (not click) your mouse cursor over the bold words in the text below to receive description

Indication
Indication
  • Nonsteroidal anti-inflammatory.
  • Fetal Risk
    Fetal Risk
  • teratogenic in animals causing skeletal defects, cleft palate, and premature closure of pulmonary artery to aorta">ductus arteriosus: blood vessel in the fetus connecting pulmonary artery to aorta">pulmonary artery to aorta">ductus arteriosus.
  • Crosses human placenta.
  • No adequate human data in first trimester but suggested possible association with cardiovascular defects.
  • If used in third trimester , it causes constriction of pulmonary artery to aorta">ductus arteriosus: blood vessel in the fetus connecting pulmonary artery to aorta">pulmonary artery to aorta">ductus arteriosus with subsequent neonatal pulmonary hypertension, oligohydramnios by affecting fetal renal function.
  • Preterm infants exposed to drug before delivery may have edema, oliguric renal failure, gastrointestinal bleeding intestinal perforation, subcutaneous bruising, intraventricular hemorrhage and absent platelet aggregation.
  • It may interact with beta-blockers causing maternal hypertension by inhibiting the effect of the latter as anti-hypertensive.
  • Can cause post-partum hemorrhage if used during labor.
  • Unknown relationship between the drug and phocomelia, and agenesis of the penis.
  • Blocks blastocyst implantation in animals so should not be used by women attempting to conceive.
  • Breast Feeding
    Breast Feeding
  • Excreted into milk.
  • Considered safe in breast feeding.
  • Reported single case of seizures in exposed infants.
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
      Tell A Friend

        You
    Name
    Email
        Your Friend
    Name
    Email
        Comments
     4   +   8    =  
      Calculate Birth Date
    Enter the first day of the last menstruation
    Month Day Year
    Result
    Month Day Year