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Generic Name
Losartan and Hydrochlorothiazide
Trade Name
Risk Category
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
The risk category is C in the first trimester.
FDA Pregnancy Risk Categories

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  • A systemic antihypertensive combination
  • Fetal Risk
    Fetal Risk
  • Inadequate human studies but the use of angiotensin converting enzyme inhibitors in the second and third trimesters is known to cause fetal anuria, renal failure, skull hypoplasia, hypotension and even neonatal death.
  • Thiazide diuretics cross the placenta and may cause thrombocytopenia and neonatal jaundice.
  • Breast Feeding
    Breast Feeding
  • Unknown excretion of Losartan into human breast milk.
  • Thiazide diuretics are excreted.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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