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Generic Name
Lisinopril and Hydrochlorothiazide
Trade Name
Prinzide
Risk Category
D*
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
The risk category is C in the first trimester.
FDA Pregnancy Risk Categories

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Indication
Indication
  • A systemic combination for treatment of hypertension and congestive heart failure.
  • Fetal Risk
    Fetal Risk
  • Inadequate studies about use during the first trimester.
  • Use in the second and third trimesters is associated with hypotension, renal failure, anuria, skull hypoplasia, and even neonatal death.
  • Breast Feeding
    Breast Feeding
  • It is not known whether lisinopril is secreted in human milk. However, milk of lactating rats contains radioactivity following administration of 14C lisinopril. In another study, lisinopril was present in rat milk at levels similar to plasma levels in the dams.
  • Thiazides do appear in human milk.
  • Because of the potential for serious reactions in nursing infants from ACE inhibitors and hydrochlorothiazide, a decision should be made whether to discontinue nursing or to discontinue Lisinopril and Hydrochlorothiazide, taking into account the importance of the drug to the mother.
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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