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Generic Name
Trade Name
Risk Category
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
FDA Pregnancy Risk Categories

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  • antineoplastic, antimetabolite.
  • Fetal Risk
    Fetal Risk
  • teratogenic in animals, no well controlled human data but suggested possible association with congenital anomalies in first trimester wxposure including: eye defects (microphthalmia, corneal opacities), cleft palate, growth retardation, hypoplasia of ovaries and thyroid gland.
  • Reported to cause bone marrow suppression and chromosomal aberrations in the newborns exposed in utero (normal karyotype but with chromosomal gaps and rings) with subsequent increased risk of cancer and genetic damage in the next generation.
  • Occupational exposure of pregnant women to antineoplastic drugs may present risk to the fetus including fetal loss and malformations.
  • Breast Feeding
    Breast Feeding
  • Data not available.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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