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Generic Name
Trade Name
Risk Category
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
FDA Pregnancy Risk Categories

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  • antineoplastic, alkylating agent.
  • Fetal Risk
    Fetal Risk
  • teratogenic in animals.
  • Crosses human placents.
  • No adequate human data but suggested possible association with congenital defects including: cranio-facial, digital, cardiovascular defects, hemangioma, rectovaginal fistula, imporforate annus inguinal and umbilical hernias.
  • Possible cause of intrauterine growth retardation.
  • Doubtful cause of chromosomal abnormalities in treated patients with subsequent genetic damage in the next generation.
  • Occupational exposure to antineoplastic agents in pregnancy carries risk to the fetus: incresing fetal loss and malformations.
  • Breast Feeding
    Breast Feeding
  • Excreted into milk.
  • Causes neutropenia, and diarrhea in exposed infants.
  • Contraindicated during breast feeding because of immune suppression, effect on growth and carcinogenesis in exposed infants.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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