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Generic Name
Diflunisal
Trade Name
Dolobid
Manufacturer
MSD
Risk Category
C
  • Studies on animals show adverse effect and toxicity on fetus.
  • No adequate and well controlled studies done on pregnant women.
  • Drugs should be given only if the potential benefit outweighs the potential risk to the fetus.
FDA Pregnancy Risk Categories

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Indication
Indication
  • Nonsteroidal anti-inflammatory agent.
  • Fetal Risk
    Fetal Risk
  • teratogenic and embryotoxic in animals.
  • Limited human data in 1st trimester.
  • Causes constriction of pulmonary artery to aorta">ductus arteriosus with subsequent neonatal pulmonary hypertension if used in 3rd trimester.
  • Inhibits labor, prolongs gestation.
  • Should not be used by women attempting to conceive because it blocks blastocyst implantation in animals.
  • Breast Feeding
    Breast Feeding
  • Diflunisal is excreted in human milk in concentrations of 2 to 7% of those in plasma.
  • Because of the potential for serious adverse reactions in nursing infants from Diflunisal, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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