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Generic Name
Trade Name
Risk Category
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
FDA Pregnancy Risk Categories

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  • chelating agent for treatment of Wilson’s disease, cystinuria and severe rheumatoid arthritis.
  • Fetal Risk
    Fetal Risk
  • Teratogenic and toxic in animals at high doses causing skeletal defects, cleft palate and fetal resorption.
  • Crosses human placenta.
  • No well controlled human data but suggested possible association with congenital malformations including: Limb, gastrointestinal, central nervous system defects, growth retardation, inguinal hernia, cerebral palsy, sudden infant death and impaired wound healing.
  • Untreated maternal Wilson’s disease during pregnancy causes accumulation of copper in fetal liver with resulting hepatomegaly, elevated liver enzymes and low serum ceruloplasmin, so drug therapy should be continued during pregnancy except the first trimester and to reduce the toxicity in the new born, it is recommended that the maternal dose be limited to 1 gm/day and if cesarean section is planned to 250 mg/day for 6 weeks before delivery and post operatively until wound healing is complete.
  • Breast Feeding
    Breast Feeding
  • Unknown excretion into breast milk.
  • Use is not recommended in nursing mothers.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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