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Generic Name
Captopril
Trade Name
Ropril
Manufacturer
Aegis
Risk Category
D*
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
The risk category is C in the first trimester.
FDA Pregnancy Risk Categories

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Indication
Indication
  • Inhibitor of angiotensin-1-converting enzyme.
  • Antihypertensive.
  • Fetal Risk
    Fetal Risk
  • Embryocidal in animals, increasing the stillbirth rate.
  • No well controlled human studies about the use of this drug in the first trimester but no association with congenital anomalies had been reported.
  • The drug is teratogenic and fetotoxic if used in second and third trimesters causing: 1. oligohydramnios leading to limb contractures, skull deformities and pulmonary hypoplasia. 2. intrauterine growth retardation. 3. renal tubular dysplasia leading to neonatal anuria and renal failure. 4. Severe neonatal hypotension. 5. premature delivery, intrauterine fetal death.
  • Breast Feeding
    Breast Feeding
  • Excreted into milk in small amounts.
  • No adverse effects on nursing infants.
  • Safe in breast feeding.
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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