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Generic Name
Estramustine phosphate
Trade Name
Estracyt Capsules
Manufacturer
Pharmacia & Upjhon
Risk Category
X
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
  • Studies in animals and/or humans have demonstrated fetal abnormalities.
  • Fetal risk involved in use of drug, clearly outweighs potential benefit.
  • Contraindicated in women who are or may become pregnant. Don’t use.
FDA Pregnancy Risk Categories

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Indication
Indication
  • antineoplastic agent containing estradiol and nor-nitrogen mustrad.
  • Fetal Risk
    Fetal Risk
  • No adequate human data, but suggested possible association with limb and kidney defects and cerebral hemorrhage whe used in first trimester.
  • Use of estrogenic hormones is contraindicated in pregnancy because of suggested possible assocation with congenital malformations (cardiovascular defects and hypospadias).
  • Occupational exposure to antineoplastic agents during pregnancy presents risk to the fetus including fetal loss and malformations.
  • Breast Feeding
    Breast Feeding
  • Estradiol is safe in breast feeding but it supresses lactation.
  • No data available about machlorethamine (nor-nitrogen mustard) in lactation
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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