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Generic Name
Trade Name
Risk Category
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
FDA Pregnancy Risk Categories

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  • Benzodiazepine.
  • Anticonvulsant, antipanic.
  • Fetal Risk
    Fetal Risk
  • Cause cleft palate, open eyelids, limb defects if used during organogenesis in animals.
  • Crosses human placenta.
  • No adequate human data but other benzodiazepines increase the risk of congenital anomalies if used in 1st trimester.
  • Chronic use in pregnancy causes neonatal withdrawal.
  • If used in last weeks of pregnancy it causes neonatal central nervous system depression, respiratory problems, poor feeding, hypothermia and neonatal flaccidity.
  • Breast Feeding
    Breast Feeding
  • Assumed to be excreted into milk because of similarity to other benzodiazepines.
  • Benzodiazepines can cause sedation, weight loss and poor feeding in nursing infants.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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