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Generic Name
Alprazolam
Trade Name
Zolam
Manufacturer
Amoun
Risk Category
D
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
FDA Pregnancy Risk Categories

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Indication
Indication
  • Benzodiazepine, sedative for treatment of anxiety.
  • Fetal Risk
    Fetal Risk
  • The drug is teratogenic in animals at high doses producing skeletal anomalies and by affecting the fetal neurodevelopment it causes cerebellar defects, reduced motivation and increased male aggression in the adult offspring exposed in utero.
  • Unknown transfer through the placenta but other benzodiazepines cross the placenta freely.
  • Suggested possible association between in utero exposure to alprazolam and triazolam with congenital anomalies , the number of exposures was too small to make a conclusion.
  • Chronic maternal use of the drug throughout pregnancy can cause neonatal withdrawal.
  • Breast Feeding
    Breast Feeding
  • Excreted into milk.
  • May cause withdrawal symptoms in nursing infants, lethargy and weight loss, so should be avoided during lactation.
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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