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Generic Name
Trade Name
Risk Category
  • Studies on animals show adverse effect and toxicity on fetus.
  • No adequate and well controlled studies done on pregnant women.
  • Drugs should be given only if the potential benefit outweighs the potential risk to the fetus.
FDA Pregnancy Risk Categories

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  • diuretic, member of thiazide group.
  • Fetal Risk
    Fetal Risk
  • Crosses human placenta.
  • No adequate human data but in general thiazides are suggested to be teratogenic increasing the risk of congenital malformations if used during first trimester of pregnancy.
  • Thiazides are diabetogenic and newborns exposed in utero are at risk of hypoglycemia.
  • neonatal hemolytic anemia and thrombocytopenia reported with thiazides' use near term.
  • Thiazides can cause maternal electrolyte imbalance (mainly hypokalemia) and hypotension leading to fetal bradycardia and neonatal hyponatremia and hypotonia.
  • Having direct effect on smooth muscles, thiazides may inhibit labor.
  • Breast Feeding
    Breast Feeding
  • Excreted into milk in small amount.
  • Thiazides are considered safe in breast feeding although they have been used to supress lactation.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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