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Generic Name
Pefloxacine
Trade Name
Peflacine 400 mg
Risk Category
No Data <ul> <li>Risk classification not available</li> </ul>
FDA Pregnancy Risk Categories

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Indication
Indication
  • Anti-bacterial.
  • Quinolone.
  • Fetal Risk
    Fetal Risk
  • Contraindicated in pregnancy and breast feeding.
  • Causes cartilage lesions of weight-bearing joints of animals exposed in utero.
  • No well controlled human data but suggested possible association between use of the drug in the first trimester and congenital malformations including spina bifida, limb defects, hypospasdia, inguinal hernia, eye/ear defects, heart and skeleton defects and teeth discoloration.
  • Reported higher rate of cesarean section for fetal distress in the pregnancies exposed to flouroquinolones and their babies were heavier.
  • In animals, high doses are teratogenic and fetotoxic causing growth retardation, increase in post-implantation loss, cartilage lesions leading to arthropathy.
  • No adequate human data but should be avoided because of potential arthropathy in infants exposed in utero.
  • Not teratogenic in animals but causes embryonic loss at high doses.
  • Crosses human placenta.
  • No well controlled human data but reported brain defects in first trimester exposure.
  • Heavier infants with longer gestation reported in fluoroquinolone exposed pregnancies.
  • Fluoroquinolones including norfloxacin are considered contraindicated in pregnancy.
  • Breast Feeding
    Breast Feeding
  • Contraindicated in pregnancy and breast feeding.
  • Exposure to quinolones with excessive sunlight causes phototoxicity and well-differentiated squamous cell carcinoma of the skin in animals, but ciprofloxacin was not studied.
  • Excreted into milk.
  • Limited human data and unknown adverse effects but should be avoided for potential cartilage damage and teeth discoloration in infants exposed.
  • Carcinogenic in animals taking the drug and exposed to excessive sunlight producing well differentiated squamous cell carcinoma of the skin.
  • No human data but should be avoided bacuase of potential arthropathy in exposed infants.
  • Should be avoided.
  • Other Trade Names
     
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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