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Generic Name
Topotecan hydrochloride
Trade Name
Topotecan hydrochloride
Risk Category
  • Positive evidence of human fetal risk exists.
  • Potential benefits may warrant use of the drug in pregnant women despite potential risks (e.g. life threatening situations or serious illness).
FDA Pregnancy Risk Categories

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  • antineoplastic agent.
  • Inhibits topoisomerase I involved in DNA replication.
  • Fetal Risk
    Fetal Risk
  • maternal neutropenia, alopecia, and vomiting.
  • Teratogenic and fetotoxic in animals causing fetal resorption, reduced fetal weight and increased incidence of malformations of the eye, brain, skull and vertebrae.
  • Containdicated in human pregnancy.
  • Breast Feeding
    Breast Feeding
  • Contraindicated.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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