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Generic Name
Calcium folinate
Trade Name
Calcium Leucovorin tablets
Risk Category
  • Studies on animals show adverse effect and toxicity on fetus.
  • No adequate and well controlled studies done on pregnant women.
  • Drugs should be given only if the potential benefit outweighs the potential risk to the fetus.
FDA Pregnancy Risk Categories

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  • Calcium Folinate (Folinic acid) is the active metabolite of folic acid.
  • Used in tablets or injection to counteract the folate antagonist action of methotrexate.
  • Has been used for treatment of megaloblastic anemia during pregnancy.
  • Fetal Risk
    Fetal Risk
  • Use only if potential benefit outweighs risk.
  • Crosses the placenta.
  • No adequate human data but high doses of vitamin B1, B6,C and folic acid were reported to cause anencephaly when used in pregnancy. High folate intake by pregnant woman may cause low serum zinc levels leading to increased pregnancy complications as: bleeding, fetal distress, prematurity and fetal death.
  • Breast Feeding
    Breast Feeding
  • Excreted into milk.
  • Safe in breast feeding.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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