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Generic Name
Thiamine (Vitamin B1)
Trade Name
Risk Category
  • Adequate and well-controlled studies have failed to demonstrate risk on fetus.
  • Possibility of fetal harm seems appears remote.
The risk category will be C only if used in doses above the RDA.
FDA Pregnancy Risk Categories

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  • Vitamin B1. Water soluble vitamin. The recommended dietary allowance (rda) in pregnancy is 1.5 mg.
  • Fetal Risk
    Fetal Risk
  • Crosses the placenta by active transport. Fetal and neonatal levels are higher than maternal.
  • Thiamine may be used to treat hyperemesis gravidarum without fetal adverse effects although pyridoxine is more effective.
  • Controversial association between high doses of thiamine intake in pregnancy and anencephaly.
  • Unproven association between thiamine deficiency and down’s syndrome, preleukemic bone marrow changes.
  • Ethanol induced thiamine deficiency is a cause of intrauterine growth retardation.
  • Breast Feeding
    Breast Feeding
  • Excreted into milk. rda during lactation is 1.6 mg.
  • Safe in breast feeding.
  • Maternal thiamine deficiency can adversely affect the nursing infant causing hypotension, metabolic acidosis, seizures, heart failure with vasoconstriction (shoshin beriberi).
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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