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Generic Name
Phytonadione (Vitamin K)
Trade Name
Vitamin K Phytonadione (Vitamin K)
Risk Category
  • Studies on animals show adverse effect and toxicity on fetus.
  • No adequate and well controlled studies done on pregnant women.
  • Drugs should be given only if the potential benefit outweighs the potential risk to the fetus.
FDA Pregnancy Risk Categories

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  • Phnytonadione and menadione are synthetic fat-soluble analogues of vitamin K for treatment of maternal hypoprothrombinemia caused by vitamin K deficiency and prevention of neonatal hemorrhagic disease.
  • The recommended dietary intake from food of vitamin K1 during pregnancy is 45 mcg.
  • Fetal Risk
    Fetal Risk
  • Poor transfer across the placenta.
  • Possible association with cardiovascular defects and spina bifida in 1st trimester exposure.
  • Not toxic in 3rd trimester and in doses less than 20mg.
  • Breast Feeding
    Breast Feeding
  • Breast milk has lower concentration of vitamin K1 than cow’s milk.
  • Safe in breast feeding.
  • Other Trade Names
    The information on this Web site is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any medications. Please read the Terms and Conditions before using this website.
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